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Symbol
Name
ID
C3
complement component 3
MGI:88227
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Stroke
Ischemic stroke
Anorexia
Dysphagia
Abnormality of the nervous system
Chorea
Depression
Psychosis
Lethargy
Headache
Seizure
Disease(s) Associated with C3
paroxysmal nocturnal hemoglobinuria
sickle cell anemia
systemic lupus erythematosus

Mouse Phenotypes
decreased cerebral infarct size
brain inflammation
abnormal hippocampus CA3 region morphology
abnormal dendritic spine morphology
increased neuron number
abnormal retina rod bipolar cell morphology
abnormal retina horizontal cell morphology
abnormal synaptic vesicle number
enhanced central nervous system regeneration
abnormal synaptic plasticity
enhanced long-term potentiation
enhanced paired-pulse facilitation
Availability Mouse Genotype
C3tm1Crr/C3tm1Crr

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory